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Friday, July 24, 2020 | History

9 edition of N-Acetylaspartate found in the catalog.

N-Acetylaspartate

A Unique Neuronal Molecule in the Central Nervous System (Advances in Experimental Medicine and Biology)

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Published by Springer .
Written in English


Edition Notes

ContributionsJohn R. Moffett (Editor), Suzannah B. Tieman (Editor), Daniel R. Weinberger (Editor), Joseph T. Coyle (Editor), Aryan M.A. Namboodiri (Editor)
The Physical Object
Number of Pages376
ID Numbers
Open LibraryOL7445232M
ISBN 100387301712
ISBN 109780387301716

NAA is the second-most-concentrated molecule in the brain after the amino acid glutamate. It is detected in the adult brain in neurons oligodendrocytes and myelin and is synthesized in the mitochondria from the amino acid aspartic acid and acetyl-coenzyme A. Magnetic resonance spectroscopy (MRS) provides useful information regarding metabolic composition in the tissues, and advanced spectroscopic methods are used to quantify markers of tumor membrane turnover and proliferation (e.g., choline (Cho)), energy homoeostasis (e.g., creatine (Cr)), intact glioneuronal structures (e.g., N-acetylaspartate (NAA)), and necrosis Author: B C Hamsini, Bhavana Nagabhushana Reddy, Sankar Neelakantan, Sunitha Palasamudram Kumaran.

Online Scientific Book Collection eBook Benefits Instantaneous and convenient access to book content wherever and whenever needed Fully searchable and hyperlinked through easy-to-use browsing and search functions Searchable on book chapter level Journals and eBooks on one platform Accessible on N-acetylaspartate Magnetic resonance spectroscopy in preterm infants: association with neurodevelopmental outcomes Reina Hyodo, Yoshiaki Sato, Miharu Ito, Yuichiro Sugiyama, Chikako Ogawa, Hisashi Kawai, Toshiki Nakane, Akiko Saito, Akihiro Hirakawa, Hiroyuki Kidokoro, Jun Natsume, Masahiro Hayakawa.

N-acetylaspartylglutamate (NAAG) in spinal cord injury and disease. In N-Acetylaspartate: A Unique Neuronal Molecule in the Central Nervous System (pp. ). (Advances in Experimental Medicine and Biology; Vol. ).Author: James L. Meyerhoff, Debra L. Yourick, Barbara S. Slusher, Joseph B. Long. Predicted data is generated using the US Environmental Protection Agency’s EPISuite™. Log Octanol-Water Partition Coef (SRC): Log Kow (KOWWIN v estimate) = Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPWIN v): Boiling Pt (deg C): (Adapted Stein & Brown method) Melting Pt (deg C): (Mean or Weighted MP) VP(mm Hg,25 deg .


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N-Acetylaspartate Download PDF EPUB FB2

N-acetylaspartate, or NAA, is the acetylated form of the amino acid aspartate, and it is present exclusively in the nervous system. Indeed, NAA is one of the most highly concentrated chemicals N-Acetylaspartate book in the brain of humans and animals, and yet the functions served by this brain-specific metabolite remain elusive, and controversial.

N-Acetylaspartic Acid. N-acetylaspartate (NAA) is an amino acid derivative, formed by the acetylation of l-aspartic acid, present in very high concentrations (up to 10mM) in mammalian brain and localized predominantly in neurons (Tallan et.

N-Acetylaspartate, or NAA, is one of the most concentrated chemicals in the human brain, but its functions are still controversial. Because of its high concentration, NAA produces a very strong signal in magnetic resonance spectrograms of the brain.5/5(2).

N-acetylaspartate, or NAA, is the acetylated form of the amino N-Acetylaspartate book aspartate, and it is present exclusively in the nervous system. Indeed, NAA is one of the most highly concentrated chemicals found in the brain of humans and animals, and yet the functions served by this brain-specific metabolite remain elusive, and controversial.

Despite the uncertainties. N-Acetylaspartate (NAA, Figure 1) is an enigmatic molecule present at exceptionally high concentrations in the brain (Tallan et al., ; Tallan, ). The levels found in various areas of the brain can reach 10mM or greater (Bluml, ; Miyake et al., ; Pan and Takahashi, ), making it one of the most concentrated molecules in the Cited by: N-acetylaspartate in the vertebrate brain: metabolism and function.

Baslow MH(1). Author information: (1)Nathan S. Kline Institute for Psychiatric Research, Old Orangeburg Road, Orangeburg, New YorkUSA. [email protected] N-Acetyl-L-aspartate (NAA) is an amino acid that is present in the vertebrate by: N-Acetylaspartate, or NAA, is one of the most concentrated chemicals in the human brain, but its functions are still controversial.

Because of its high concentration, NAA produces a very strong signal in magnetic resonance spectrograms of the brain. This signal is reduced in many different brain disorders and diseases, making NAA a valuable 5/5(2).

N-Acetylaspartic acid, or N-acetylaspartate (NAA), is a derivative of aspartic acid with a formula of C 6 H 9 NO 5 and a molecular weight of NAA is the second-most-concentrated molecule in the brain after the amino acid is detected in the adult brain in neurons, oligodendrocytes and myelin and is synthesized in the mitochondria from the amino acid Beilstein Reference: S.

PDF files on NAA, NAAG and Canavan disease. Download File Now Download File Now. N-acetylaspartate (NAA) is one of the more important compounds assessed on MR spectroscopy, and resonates at ppm chemical shift (its concentration in healthy adults is mM) The synthesis of NAA, adenosine diphosphate-dependent, occurs in the neuronal mitochondria NAA is the acetylated form of the amino acid, aspartate, which is found in high concentrations.

Proton magnetic resonance spectroscopy ([sup.1]H MRS) is a useful tool that detects brain metabolites such as NAA (N-acetylaspartate), a marker for neuronal integrity or neuronal-glial homeostasis; Glx (GABA, glutamine, and glutamate); Cho (choline containing compounds), a measure of cellular density; Cr (creatine plus phosphocreatine), a marker of cellular energy.

N-acetylaspartate, or NAA, is the acetylated form of the amino acid aspartate, and it is present exclusively in the nervous system. Indeed, NAA is one of. To evaluate the contribution of cellular dysfunction and neuronal loss to brain N‐acetylaspartate (NAA) depletion, NAA was measured in brain tissue.

ISBN: OCLC Number: Notes: "First International Symposium on N-acetylaspartate (NAA) was held on September 13th and 14th, in the Natcher Conference Center at the NIH, in Bethesda, Maryland"--Page vii.

N-acetylaspartate: (as'ĕ-til-as-par'tāt), An acetylated derivative of aspartate found in the brain. Used as a marker in brain nuclear magnetic resonance and in neuroimaging.

N-Acetylaspartate: A Unique Neuronal Molecule in the Central Nervous System (Advances in Experimental Medicine and Biology Book ) eBook: Moffett, John, Tieman 5/5(1). N-Acetylaspartate in Normal Brain and Cerebral Ischemia. N-Acetylaspartic acid, discovered in by Tallan (61), is the major peak seen in water-suppressed NMR proton (hydrogen) spectroscopy at a resonance of ppm, although N-acetylaspartylglutamate also.

N-Acetylaspartylglutamic acid (N-acetylaspartylglutamate or NAAG) is a peptide neurotransmitter and the third-most-prevalent neurotransmitter in the mammalian nervous system.

NAAG consists of N-acetylaspartic acid (NAA) and glutamic acid coupled via a peptide bond. NAAG was discovered as a nervous system-specific peptide in by Curatolo and colleagues but CAS Number: M. Miyake, Y. Kakimoto and M. Sorimachi, A gas chromatographic method for the determination of N-acetyl-L-aspartic acid, N-acetyl-aspartylglutamic acid and beta-citryl-L-glutamic acid and their distributions in the brain and other organs of various species of by: N-acetylaspartate (NAA), the acetylated form of the amino acid aspartate, is one of the most highly concentrated chemicals in the brains of humans, yet its function remains elusive.

NAA is used in nonsurgical analyses of nerve cell dysfunction, and it is implicated in a disorder known as Canavan's disease.

N-acetylaspartate (NAA) is a small amino acid synthesized by neuronal mitochondria, which can be released in the extracellular space after reperfusion in animal models of brain ischemia. BACKGROUND AND PURPOSE: The most abundant metabolite visible by proton magnetic resonance spectroscopy (MRS) in human brain is N-acetylaspartate (NAA), which is often used as a marker of viable neurons.

NAA is anecdotally reported to be elevated in children with sickle cell disease (SCD), even though patients can have brain injury or atrophy. We Cited by: N-Acetylaspartate is the second most abundant amino acid in the central nervous system and is reliably measured by proton magnetic resonance spectroscopy (1H-MRS).

N-Acetylaspartate is formed in mitochondria from acetyl co-enzyme A and aspartate by the membrane-bound enzyme L-aspartate N-acetyltransferase, an enzyme selectively found in brain (12).